The linear optimization model of a complex health condition of a biological object on the example of a combination drug with local action. The optimization criterion: irritant effect (%) after applying(It was formed by the optimization criterion of the object and the state formalized the problem of determining the optimum state of the object. Next were discussed options for addressing the problem. Formalize the task and able to use the Matlab, calculate the optimal composition of the drug and identified the extreme value of the objective function. The reaction of the optimal solution of the problem when changing limits and accidental exposure. With the application can change all the parameters in real time and to track changes as a result of the program.)