The existence of numerous imaging modalities makes it possible to present different data present in different modalities together thus forming multimodal images. Component images forming multimodal images should be aligned, or registered so that all the data, coming from the different modalities, are displayed in proper locations. The term image registration is most commonly used to denote the process of alignment of images , that is of transforming them to the common coordinate system. This is done by optimizing a similarity measure between the two images. A widely used measure is Mutual Information (MI). This method requires estimating joint histogram of the two images. Experiments are presented that demonstrate the approach. The technique is intensity-based rather than feature-based. As a comparative assessment the performance based on normalized mutual information and cross correlation as metric have also been presented.-The existence of numerous imaging modalities makes it possible to present different data present in different modalities together thus forming multimodal images. Component images forming multimodal images should be aligned, or registered so that all the data, coming from the different modalities, are displayed in proper locations. The term image registration is　most commonly used to denote the process of alignment of images , that is of transforming them to the common coordinate system. This is done by optimizing a similarity measure between the two images. A widely used measure is Mutual Information (MI). This method requires estimating joint histogram of the two images. Experiments are presented that demonstrate the approach. The technique is intensity-based rather than feature-based. As a comparative assessment the performance based on normalized mutual information and cross correlation as metric have also been presented.