在数据采集系统中，USB接口技术以其高传输速度，简便的连接，以及其高通用性和高稳定性，比PCI等其他采集更适合与计算机的通信。本文系统介绍了基于USB2.0接口的数据采集系统的开发过程，以及硬件设计、固件、驱动和应用程序的设计等。本系统可实现模拟信号的采样和多路开关量输入、输出。并可通过对USB接口芯片可编程控制接口的设计实现数据的高速连续采样和传输。-Data Acquisition System, USB interface technology with a high transmission speed, ease of connectivity, and its high versatility and high stability over other PCI Acquisition is more suitable for computer communications. This paper introduced a system based on USB2.0 interface data acquisition system development process, and hardware design, firmware, Driver, and application of design. The system can be realized analog signal sampling and multi-switch input and output. Accessible through the USB interface chip programmable control interface design to achieve high-speed data transmission and continuous sampling.