Economic loss estimation for earthquake hazard in Istanbul-Natural hazards, especially earthquakes, cause disasters when they hit large settlements such as metropolitan areas. After the first shock, the damage is counted by deaths and injuries. In a while, the destroying effects of disaster appear on economic asset of the region. Direct losses including damages in buildings and lifelines can caused non-structural or indirect losses as interruption of business activities and services. Loss estimation techniques have been developed to evaluate losses from earthquakes and other natural hazards. Recently, loss estimation models have improved due to advances in information technology and have been automated using Geographic Information Systems.